About the Authors

Giovanni Di Pasquale

Contributed equally to this work with: Giovanni Di Pasquale, Ilaria Dicembrini

Affiliation Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

Ilaria Dicembrini

Contributed equally to this work with: Giovanni Di Pasquale, Ilaria Dicembrini

Affiliation Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Florence, Italy

Laura Raimondi

Affiliation Department of Pharmacology, University of Florence, Florence, Italy

Claudio Pagano

Affiliation Endocrine-metabolic Laboratory, Department of Medical and Surgical Sciences, University of Padua, Padua, Italy

Josephine M. Egan

Affiliation Diabetes Section, National Institute on Aging and Health, Baltimore, Maryland, United States of America

Andrea Cozzi

Affiliation Department of Pharmacology, University of Florence, Florence, Italy

Lorenzo Cinci

Affiliation Section of Histology, Department of Anatomy, University of Florence, Florence, Italy

Andrea Loreto

Affiliation Department of Pharmacology, University of Florence, Florence, Italy

Maria E. Manni

Affiliation Department of Pharmacology, University of Florence, Florence, Italy

Silvia Berretti

Affiliation Department of Pharmacology, University of Florence, Florence, Italy

Annamaria Morelli

Affiliation Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy

Changyu Zheng

Affiliation Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

Drew G. Michael

Affiliation Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

Mario Maggi

Affiliation Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy

Roberto Vettor

Affiliation Endocrine-metabolic Laboratory, Department of Medical and Surgical Sciences, University of Padua, Padua, Italy

John A. Chiorini

jchiorini@dir.nidcr.nih.gov (JAC); c.rotella@dfc.unifi.it (CMR)

Affiliation Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

Edoardo Mannucci

These authors also contributed equally to this work.

Affiliation Diabetes Agency, Careggi Teaching Hospital, Florence, Italy

Carlo M. Rotella

jchiorini@dir.nidcr.nih.gov (JAC); c.rotella@dfc.unifi.it (CMR)

These authors also contributed equally to this work.

Affiliation Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Florence, Italy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GDP ID JAC EM CMR. Performed the experiments: GDP ID LR CP JME AC LC AL MEM SB AM CZ DGM MM RV. Analyzed the data: GDP ID JAC EM CMR. Contributed reagents/materials/analysis tools: JME. Wrote the paper: GDP ID JAC EM CMR.