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Research Article

Cardioprotection of Controlled and Cardiac-Specific Over-Expression of A2A-Adenosine Receptor in the Pressure Overload

  • Eman A. Hamad,

    Affiliations: Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Medicine, The Center for Translational Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America

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  • Weizhong Zhu mail,

    Arthur.Feldman@Temple.edu (AMF); Weizhong.Zhu@Temple.edu (WZ)

    Affiliation: Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Tung O. Chan,

    Affiliation: Department of Medicine, The Center for Translational Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America

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  • Valerie Myers,

    Affiliation: Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Erhe Gao,

    Affiliation: Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Xue Li,

    Affiliation: Department of Medicine, The Center for Translational Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America

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  • Jin Zhang,

    Affiliation: Department of Medicine, The Center for Translational Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America

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  • Jianliang Song,

    Affiliation: Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Xue-Qian Zhang,

    Affiliation: Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Joseph Y. Cheung,

    Affiliation: Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Walter Koch,

    Affiliation: Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Arthur M. Feldman mail

    Arthur.Feldman@Temple.edu (AMF); Weizhong.Zhu@Temple.edu (WZ)

    Affiliation: Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: July 06, 2012
  • DOI: 10.1371/journal.pone.0039919

About the Authors

Eman A. Hamad, Weizhong Zhu, Valerie Myers, Erhe Gao, Jianliang Song, Xue-Qian Zhang, Joseph Y. Cheung, Walter Koch, Arthur M. Feldman
Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
Eman A. Hamad, Tung O. Chan, Xue Li, Jin Zhang
Department of Medicine, The Center for Translational Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EAH WZZ TOC AMF. Performed the experiments: EAH WZZ TOC VM EHG XL JZ JLS XQZ. Analyzed the data: EAH WZZ TOC JYC WK AMF. Contributed reagents/materials/analysis tools: VM JZ. Wrote the paper: WZZ TOC AFM.