Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles

Janni Papakrivos; Juliana M. Sá; Thomas E. Wellems

doi:10.1371/journal.pone.0039569

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Open Access

Peer-reviewed

Research Article

Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles

Janni Papakrivos,

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Juliana M. Sá,

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Thomas E. Wellems

* E-mail: twellems@niaid.nih.gov

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles

Janni Papakrivos,
Juliana M. Sá,
Thomas E. Wellems

Published: June 19, 2012
https://doi.org/10.1371/journal.pone.0039569

About the Authors

Janni Papakrivos

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Juliana M. Sá

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Thomas E. Wellems

* E-mail: twellems@niaid.nih.gov

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JP JMS TEW. Performed the experiments: JP. Analyzed the data: JP JMS TEW. Contributed reagents/materials/analysis tools: JP JMS TEW. Wrote the paper: JP TEW.

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Vesicles
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Dictyostelium discoideum
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Membrane potential
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Ammonia
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Plasmodium
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Ionophores
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Centrifugation
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Electrochemistry
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