Advertisement
Research Article

Targeting Anticancer Drug Delivery to Pancreatic Cancer Cells Using a Fucose-Bound Nanoparticle Approach

  • Makoto Yoshida,

    Affiliations: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Division of Clinical Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan

    X
  • Rishu Takimoto,

    Affiliations: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Division of Clinical Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan

    X
  • Kazuyuki Murase,

    Affiliation: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

    X
  • Yasushi Sato,

    Affiliation: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

    X
  • Masahiro Hirakawa,

    Affiliations: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Division of Clinical Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan

    X
  • Fumito Tamura,

    Affiliations: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Division of Clinical Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan

    X
  • Tsutomu Sato,

    Affiliations: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Division of Molecular Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan

    X
  • Satoshi Iyama,

    Affiliation: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

    X
  • Takahiro Osuga,

    Affiliation: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

    X
  • Koji Miyanishi,

    Affiliation: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

    X
  • Kohichi Takada,

    Affiliation: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

    X
  • Tsuyoshi Hayashi,

    Affiliation: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

    X
  • Masayoshi Kobune,

    Affiliation: Division of Molecular Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan

    X
  • Junji Kato mail

    jkato@sapmed.ac.jp

    Affiliations: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Division of Clinical Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan

    X
  • Published: July 11, 2012
  • DOI: 10.1371/journal.pone.0039545

About the Authors

Makoto Yoshida, Rishu Takimoto, Kazuyuki Murase, Yasushi Sato, Masahiro Hirakawa, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Takahiro Osuga, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Junji Kato
Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
Makoto Yoshida, Rishu Takimoto, Masahiro Hirakawa, Fumito Tamura, Junji Kato
Division of Clinical Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan
Tsutomu Sato, Masayoshi Kobune
Division of Molecular Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan

Corresponding Author

Email: jkato@sapmed.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RT JK. Performed the experiments: MY RT K. Murase YS MH FT TO. Analyzed the data: RT JK. Contributed reagents/materials/analysis tools: TS K. Miyanishi SI KT TH MK. Wrote the paper: RT YM JK.