Advertisement
Research Article

Genetic Ancestry-Smoking Interactions and Lung Function in African Americans: A Cohort Study

  • Melinda C. Aldrich equal contributor mail,

    equal contributor Contributed equally to this work with: Melinda C. Aldrich, Rajesh Kumar

    melinda.aldrich@vanderbilt.edu

    Affiliations: Division of Epidemiology, Department of Thoracic Surgery, Vanderbilt University, Nashville, Tennessee, United States of America, Departments of Medicine and Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

    X
  • Rajesh Kumar equal contributor,

    equal contributor Contributed equally to this work with: Melinda C. Aldrich, Rajesh Kumar

    Affiliation: Children's Memorial Hospital, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Laura A. Colangelo,

    Affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • L. Keoki Williams,

    Affiliation: Center for Health Policy and Health Services Research and Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, United States of America

    X
  • Saunak Sen,

    Affiliation: Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

    X
  • Stephen B. Kritchevsky,

    Affiliation: Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Bernd Meibohm,

    Affiliation: College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

    X
  • Joshua Galanter,

    Affiliation: Departments of Medicine and Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

    X
  • Donglei Hu,

    Affiliation: Departments of Medicine and Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

    X
  • Christopher R. Gignoux,

    Affiliation: Departments of Medicine and Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

    X
  • Yongmei Liu,

    Affiliation: Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, North Carolina, United States of America

    X
  • Tamara B. Harris,

    Affiliation: Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Elad Ziv,

    Affiliation: Departments of Medicine and Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

    X
  • Joseph Zmuda,

    Affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Melissa Garcia,

    Affiliation: Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Tennille S. Leak,

    Affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Marilyn G. Foreman,

    Affiliation: Division of Pulmonary and Critical Care Medicine, Morehouse School of Medicine, Atlanta, Georgia, United States of America

    X
  • Lewis J. Smith,

    Affiliation: Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Myriam Fornage,

    Affiliation: Institute of Molecular Medicine and Division of Epidemiology, School of Public Health, University of Texas Health Sciences Center, Houston, Texas, United States of America

    X
  • Kiang Liu,

    Affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Esteban G. Burchard,

    Affiliation: Departments of Medicine and Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

    X
  • for the Health ABC and CARDIA Studies
  • Published: June 21, 2012
  • DOI: 10.1371/journal.pone.0039541

About the Authors

Melinda C. Aldrich
Division of Epidemiology, Department of Thoracic Surgery, Vanderbilt University, Nashville, Tennessee, United States of America
Melinda C. Aldrich, Joshua Galanter, Donglei Hu, Christopher R. Gignoux, Elad Ziv, Esteban G. Burchard
Departments of Medicine and Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America
Rajesh Kumar
Children's Memorial Hospital, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
Laura A. Colangelo, Kiang Liu
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
L. Keoki Williams
Center for Health Policy and Health Services Research and Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, United States of America
Saunak Sen
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
Stephen B. Kritchevsky
Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Bernd Meibohm
College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
Yongmei Liu
Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, North Carolina, United States of America
Tamara B. Harris, Melissa Garcia
Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
Joseph Zmuda, Tennille S. Leak
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Marilyn G. Foreman
Division of Pulmonary and Critical Care Medicine, Morehouse School of Medicine, Atlanta, Georgia, United States of America
Lewis J. Smith
Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
Myriam Fornage
Institute of Molecular Medicine and Division of Epidemiology, School of Public Health, University of Texas Health Sciences Center, Houston, Texas, United States of America

Corresponding Author

Email: melinda.aldrich@vanderbilt.edu

Competing Interests

The authors have read the journal's policy and have the following conflicts: Dr. Aldrich has served as a Guest Editor for PLoS ONE. Christopher R. Gignoux holds stock with 23andMe, Inc. Dr. Smith received consultancy funds from Karmel-Sonix. Dr. Williams has received funding from Merck & Co for speaking engagements and travel. No other disclosures were reported. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MCA RK SBK BM YL EGB. Performed the experiments: MCA SBK BM CRG YL TBH EZ JZ MG TSL MF KL LJS EGB. Analyzed the data: MCA RK LAC LKW SS KL JG DH CRG YL MG MGF EGB. Contributed reagents/materials/analysis tools: YL. Wrote the paper: MCA RK EGB. Critical revision of the manuscript for important intellectual content: MCA RK LAC LKW SS SBK BM JG DH CRG YL TBH EZ JZ MG TSL MGF LJS MF KL EGB. Final approval of the version to be published: MCA RK LAC LKW SS SBK BM JG DH CRG YL TBH EZ JZ MG TSL MGF LJS MF KL EGB.