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Research Article

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo

  • Elodie Angot mail,

    Elodie.Angot@med.lu.se

    Affiliation: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

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  • Jennifer A. Steiner,

    Affiliations: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

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  • Carla M. Lema Tomé,

    Affiliation: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

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  • Peter Ekström,

    Affiliation: ImaGene-iT, Lund, Sweden

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  • Bengt Mattsson,

    Affiliation: Neurobiology Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

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  • Anders Björklund,

    Affiliation: Neurobiology Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

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  • Patrik Brundin

    Affiliations: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

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  • Published: June 21, 2012
  • DOI: 10.1371/journal.pone.0039465

About the Authors

Elodie Angot, Jennifer A. Steiner, Carla M. Lema Tomé, Patrik Brundin
Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
Jennifer A. Steiner, Patrik Brundin
Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
Peter Ekström
ImaGene-iT, Lund, Sweden
Bengt Mattsson, Anders Björklund
Neurobiology Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

Corresponding Author

Email: Elodie.Angot@med.lu.se

Competing Interests

The authors have the following interest: Peter Ekström is an employee of ImaGene-iT, Lund, Sweden. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: EA PB. Performed the experiments: EA JS CLT BM. Analyzed the data: EA PB. Contributed reagents/materials/analysis tools: PE AB. Wrote the paper: EA JS PB. Edited the manuscript: PE AB.