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Research Article

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

  • Steven D. Kunkel,

    Affiliations: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America

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  • Christopher J. Elmore,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Kale S. Bongers,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Scott M. Ebert,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Daniel K. Fox,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Michael C. Dyle,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Steven A. Bullard,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Christopher M. Adams mail

    christopher-adams@uiowa.edu

    Affiliations: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America

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  • Published: June 20, 2012
  • DOI: 10.1371/journal.pone.0039332

About the Authors

Steven D. Kunkel, Christopher J. Elmore, Kale S. Bongers, Scott M. Ebert, Daniel K. Fox, Michael C. Dyle, Steven A. Bullard, Christopher M. Adams
Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America
Steven D. Kunkel, Christopher M. Adams
Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America

Corresponding Author

Email: christopher-adams@uiowa.edu

Competing Interests

The University of Iowa Research Foundation has applied for patents related to this work (WO/2011/146768/A1, /PCT/US2011/037238, Methods for Inhibiting Muscle Atrophy). The authors also declare that CMA is a co-founder and officer of Emmyon, Inc. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SDK CMA. Performed the experiments: SDK CJE KSB SME DKF MCD SAB. Analyzed the data: SDK CJE CMA. Wrote the paper: SDK CMA.