About the Authors

Hans Van Remoortel

Contributed equally to this work with: Hans Van Remoortel, Yogini Raste

Affiliation Faculty of Kinesiology and Rehabilitation Sciences, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, and Respiratory Division, UZ Gasthuisberg, Leuven, Belgium

Yogini Raste

Contributed equally to this work with: Hans Van Remoortel, Yogini Raste

Affiliation NIHR Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, United Kingdom

Zafeiris Louvaris

Affiliation Thorax Foundation, Research Centre of Intensive and Emergency Thoracic Medicine, and Department of Physical Education and Sports Sciences, National and Kapodistrian University of Athens, Athens, Greece

Santiago Giavedoni

Affiliation ELEGI Colt Laboratory, Centre for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Chris Burtin

Affiliation Faculty of Kinesiology and Rehabilitation Sciences, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, and Respiratory Division, UZ Gasthuisberg, Leuven, Belgium

Daniel Langer

Affiliation Faculty of Kinesiology and Rehabilitation Sciences, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, and Respiratory Division, UZ Gasthuisberg, Leuven, Belgium

Frederick Wilson

Affiliation Precision Medicine, Pfizer Worldwide Research and Development, Sandwich, Kent, United Kingdom

Roberto Rabinovich

Affiliation ELEGI Colt Laboratory, Centre for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Ioannis Vogiatzis

Affiliation Thorax Foundation, Research Centre of Intensive and Emergency Thoracic Medicine, and Department of Physical Education and Sports Sciences, National and Kapodistrian University of Athens, Athens, Greece

Nicholas S. Hopkinson

Affiliation NIHR Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, United Kingdom

Thierry Troosters

thierry.troosters@med.kuleuven.be

Affiliation Faculty of Kinesiology and Rehabilitation Sciences, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, and Respiratory Division, UZ Gasthuisberg, Leuven, Belgium

on behalf of PROactive consortium

Membership of the PROactive Consortium is provided in the Acknowledgments.

Competing Interests

Frederick Wilson is employed by Pfizer Ltd and holds share options in Pfizer Inc. There are no patents, products in development, or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TT. Performed the experiments: HVR YR ZL SG CB DL FW RR IV NSH TT. Analyzed the data: HVR YR ZL SG CB DL FW RR IV NSH TT. Wrote the paper: HVR YR.