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Research Article

PD-1 Blockage Reverses Immune Dysfunction and Hepatitis B Viral Persistence in a Mouse Animal Model

  • Horng-Tay Tzeng,

    Affiliation: Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Hwei-Fang Tsai,

    Affiliations: Department of Internal Medicine, Taipei Medical University, Shuang Ho Hospital, Taipei, Taiwan, Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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  • Hsiu-Jung Liao,

    Affiliation: Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Yi-Jiun Lin,

    Affiliation: Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Lieping Chen,

    Affiliation: Cancer Immunology Program at Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Pei-Jer Chen,

    Affiliations: Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan, Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Ping-Ning Hsu mail

    phsu8635@ntu.edu.tw

    Affiliations: Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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  • Published: June 22, 2012
  • DOI: 10.1371/journal.pone.0039179

About the Authors

Horng-Tay Tzeng, Hsiu-Jung Liao, Ping-Ning Hsu
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
Hwei-Fang Tsai
Department of Internal Medicine, Taipei Medical University, Shuang Ho Hospital, Taipei, Taiwan
Hwei-Fang Tsai
Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Yi-Jiun Lin, Pei-Jer Chen
Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
Lieping Chen
Cancer Immunology Program at Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, United States of America
Pei-Jer Chen
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
Ping-Ning Hsu
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

Corresponding Author

Email: phsu8635@ntu.edu.tw

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PNH PJC. Performed the experiments: HTT HFT HJL YJL. Analyzed the data: PJC HFT PNH. Contributed reagents/materials/analysis tools: LC HFT. Wrote the paper: HTT PNH.