Advertisement
Research Article

Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy

  • Dhruv Sareen equal contributor mail,

    equal contributor Contributed equally to this work with: Dhruv Sareen, Allison D. Ebert

    sareend@cshs.org (DS); aebert@mcw.edu (ADE); Clive.Svendsen@cshs.org (CNS)

    Affiliation: Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

    X
  • Allison D. Ebert equal contributor mail,

    equal contributor Contributed equally to this work with: Dhruv Sareen, Allison D. Ebert

    sareend@cshs.org (DS); aebert@mcw.edu (ADE); Clive.Svendsen@cshs.org (CNS)

    Affiliation: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

    X
  • Brittany M. Heins,

    Affiliation: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

    X
  • Jered V. McGivern,

    Affiliation: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

    X
  • Loren Ornelas,

    Affiliation: Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

    X
  • Clive N. Svendsen mail

    sareend@cshs.org (DS); aebert@mcw.edu (ADE); Clive.Svendsen@cshs.org (CNS)

    Affiliation: Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

    X
  • Published: June 19, 2012
  • DOI: 10.1371/journal.pone.0039113

About the Authors

Dhruv Sareen, Loren Ornelas, Clive N. Svendsen
Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Allison D. Ebert, Brittany M. Heins, Jered V. McGivern
Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DS ADE CNS. Performed the experiments: DS ADE BMH JVM LO. Analyzed the data: DS ADE CNS. Contributed reagents/materials/analysis tools: DS ADE JVM CNS. Wrote the paper: DS ADE CNS.