About the Authors

Hilary Whitworth

Affiliation Departments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, United States of America

Shriti Bhadel

Affiliation Departments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, United States of America

Melissa Ivey

Affiliation Departments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, United States of America

Mark Conaway

Affiliations Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America, Cancer Center Member, University of Virginia, Charlottesville, Virginia, United States of America

Andrea Spencer

Affiliation Sigma-Aldrich Biotechnology, St. Louis, Missouri, United States of America

Ronald Hernan

Affiliation Sigma-Aldrich Biotechnology, St. Louis, Missouri, United States of America

Heather Holemon

Affiliation Sigma-Aldrich Biotechnology, St. Louis, Missouri, United States of America

Daniel Gioeli

dgioeli@virginia.edu

Affiliations Departments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, United States of America, Cancer Center Member, University of Virginia, Charlottesville, Virginia, United States of America

Competing Interests

The authors have read the journal’s policy and have the following conflicts: Andrea Spencer, Ronald Hernan, and Heather Holemon were employed at Sigma-Aldrich Biotechnology during the RNAi screen. Sigma-Aldrich sells the MISSION library that was used in this study. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DG RH HH. Performed the experiments: HW SB MI AS. Analyzed the data: HW SB MI MC AS RH HH DG. Contributed reagents/materials/analysis tools: RH HH MC DG. Wrote the paper: HW DG.