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Research Article

Metabolomic Profiling Reveals Mitochondrial-Derived Lipid Biomarkers That Drive Obesity-Associated Inflammation

  • Brante P. Sampey,

    Affiliation: Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    Current address: Metabolon, Inc., Durham, North Carolina, United States of America

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  • Alex J. Freemerman,

    Affiliation: Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Jimmy Zhang,

    Affiliation: Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Pei-Fen Kuan,

    Affiliations: Department of Biostatistics, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Joseph A. Galanko,

    Affiliation: Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Thomas M. O'Connell,

    Affiliation: LipoScience Inc., Raleigh, North Carolina, United States of America

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  • Olga R. Ilkayeva,

    Affiliation: Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Michael J. Muehlbauer,

    Affiliation: Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Robert D. Stevens,

    Affiliation: Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Christopher B. Newgard,

    Affiliations: Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Heather A. Brauer,

    Affiliation: Department of Epidemiology, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Melissa A. Troester,

    Affiliations: Department of Epidemiology, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Liza Makowski mail

    liza.makowski@unc.edu

    Affiliations: Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: June 12, 2012
  • DOI: 10.1371/journal.pone.0038812

About the Authors

Brante P. Sampey, Alex J. Freemerman, Jimmy Zhang, Liza Makowski
Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Pei-Fen Kuan
Department of Biostatistics, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Heather A. Brauer, Melissa A. Troester
Department of Epidemiology, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Joseph A. Galanko
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Pei-Fen Kuan, Melissa A. Troester, Liza Makowski
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Olga R. Ilkayeva, Michael J. Muehlbauer, Robert D. Stevens, Christopher B. Newgard
Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America
Christopher B. Newgard
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
Thomas M. O'Connell
LipoScience Inc., Raleigh, North Carolina, United States of America

Corresponding Author

Email: liza.makowski@unc.edu

Competing Interests

The authors declare the following interests: The project was partially funded by A Freedom to Discover Award from Bristol Meyers Squibb (http://www.bms.com/foundation/what_we_support/Pages/ftd_grants_awards.aspx) to C.B.N. B.P.S. and T.M.O. were employed at UNC while analysis of this manuscript was completed, and currently are employed by Metabolon, Inc. and Liposcience, Inc., respectively. There are no declarations relating to employment, consultancy, patents or products in development or marketed products, etc. with regard to this work. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LM BPS CBN. Performed the experiments: LM BPS AJF JZ. Analyzed the data: PFK TMO JAG HAB MAT LM. Contributed reagents/materials/analysis tools: LM CBN MAT. Wrote the paper: LM BPS CBN. Metabolomics core: ORI MJM RDS.