The Bimodal Lifestyle of Intracellular Salmonella in Epithelial Cells: Replication in the Cytosol Obscures Defects in Vacuolar Replication

Preeti Malik-Kale; Seth Winfree; Olivia Steele-Mortimer

doi:10.1371/journal.pone.0038732

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Open Access

Peer-reviewed

Research Article

The Bimodal Lifestyle of Intracellular Salmonella in Epithelial Cells: Replication in the Cytosol Obscures Defects in Vacuolar Replication

Preeti Malik-Kale ,

Contributed equally to this work with: Preeti Malik-Kale, Seth Winfree

Affiliation Salmonella Host-Cell Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, United States of America
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Seth Winfree ,

Contributed equally to this work with: Preeti Malik-Kale, Seth Winfree

Affiliation Salmonella Host-Cell Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Olivia Steele-Mortimer

* E-mail: omortimer@niaid.nih.gov

Affiliation Salmonella Host-Cell Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, United States of America
⨯

The Bimodal Lifestyle of Intracellular Salmonella in Epithelial Cells: Replication in the Cytosol Obscures Defects in Vacuolar Replication

Preeti Malik-Kale,
Seth Winfree,
Olivia Steele-Mortimer

Published: June 13, 2012
https://doi.org/10.1371/journal.pone.0038732

About the Authors

Preeti Malik-Kale

Contributed equally to this work with: Preeti Malik-Kale, Seth Winfree

Affiliation Salmonella Host-Cell Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, United States of America

Seth Winfree

Contributed equally to this work with: Preeti Malik-Kale, Seth Winfree

Olivia Steele-Mortimer

* E-mail: omortimer@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PMK SW OSM. Performed the experiments: PMK SW. Analyzed the data: PMK SW OSM. Contributed reagents/materials/analysis tools: PMK SW OSM. Wrote the paper: PMK SW OSM.

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Salmonella
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Salmonellosis
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Salmonella typhimurium
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HeLa cells
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Intracellular pathogens
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Dextran
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Epithelial cells
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Cell membranes
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