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Research Article

Correction of Liver Steatosis by a Hydrophobic Iminosugar Modulating Glycosphingolipids Metabolism

  • Elisa Lombardo,

    Affiliation: Departments of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Cindy P. A. A. van Roomen,

    Affiliation: Departments of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Gijs H. van Puijvelde,

    Affiliation: Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, Leiden, The Netherlands

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  • Roelof Ottenhoff,

    Affiliation: Departments of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Marco van Eijk,

    Affiliation: Departments of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Jan Aten,

    Affiliation: Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Johan Kuiper,

    Affiliation: Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, Leiden, The Netherlands

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  • Herman S. Overkleeft,

    Affiliation: Division of Biopharmaceutics, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

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  • Albert K. Groen,

    Affiliation: Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands

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  • Arthur J. Verhoeven,

    Affiliation: Departments of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Johannes M. F. G. Aerts mail,

    j.m.aerts@amc.uva.nl

    Affiliation: Departments of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Florence Bietrix

    Affiliation: Departments of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0038520

About the Authors

Elisa Lombardo, Cindy P. A. A. van Roomen, Roelof Ottenhoff, Marco van Eijk, Arthur J. Verhoeven, Johannes M. F. G. Aerts, Florence Bietrix
Departments of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Gijs H. van Puijvelde, Johan Kuiper
Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, Leiden, The Netherlands
Jan Aten
Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Herman S. Overkleeft
Division of Biopharmaceutics, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
Albert K. Groen
Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands

Corresponding Author

Email: j.m.aerts@amc.uva.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EL AKG AJV JMA FB. Performed the experiments: EL CPAAR GHP RO FB. Analyzed the data: EL GHP ME JA JK HSO AKG AJV JMA FB. Contributed reagents/materials/analysis tools: JA GHP JK HSO. Wrote the paper: EL ME AJV JMA FB.