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Research Article

Urinary Copper Elevation in a Mouse Model of Wilson's Disease Is a Regulated Process to Specifically Decrease the Hepatic Copper Load

  • Lawrence W. Gray,

    Affiliation: Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

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  • Fangyu Peng,

    Affiliation: Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Shannon A. Molloy,

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Venkata S. Pendyala,

    Affiliation: Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

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  • Abigael Muchenditsi,

    Affiliation: Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

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  • Otto Muzik,

    Affiliation: Carman and Ann Adams Department of Pediatrics and Department of Radiology, Wayne State University, School of Medicine, Detroit, Michigan, United States of America

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  • Jaekwon Lee,

    Affiliation: Redox Biology Center, Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, United States of America

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  • Jack H. Kaplan,

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Svetlana Lutsenko mail

    lutsenko@jhmi.edu

    Affiliation: Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

    X
  • Published: June 22, 2012
  • DOI: 10.1371/journal.pone.0038327

About the Authors

Lawrence W. Gray, Venkata S. Pendyala, Abigael Muchenditsi, Svetlana Lutsenko
Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America
Fangyu Peng
Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Shannon A. Molloy, Jack H. Kaplan
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America
Otto Muzik
Carman and Ann Adams Department of Pediatrics and Department of Radiology, Wayne State University, School of Medicine, Detroit, Michigan, United States of America
Jaekwon Lee
Redox Biology Center, Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, United States of America

Corresponding Author

Email: lutsenko@jhmi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LWG FP SAM JHK SL. Performed the experiments: LWG FP SAM VSP AM OM JL. Analyzed the data: LWG FP SAM VSP AM OM JHK SL. Wrote the paper: LWG FP SL.