About the Authors

Shin-ichiro Miura

Contributed equally to this work with: Shin-ichiro Miura, Yoshihiro Kiya

miuras@cis.fukuoka-u.ac.jp

Affiliations Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan, Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, United States of America

Yoshihiro Kiya

Contributed equally to this work with: Shin-ichiro Miura, Yoshihiro Kiya

Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

Hiroyuki Hanzawa

Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan

Naoki Nakao

Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan

Masahiro Fujino

Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

Satoshi Imaizumi

Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

Yoshino Matsuo

Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

Hiroaki Yanagisawa

Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan

Hiroyuki Koike

Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan

Issei Komuro

Affiliation Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan

Sadashiva S. Karnik

Affiliation Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, United States of America

Keijiro Saku

Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

Competing Interests

HH, NN, HY and HK are employed by a commercial company, Daiichi Sankyo Company, Ltd. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SM YK. Performed the experiments: YK HH NN MF SI YM. Analyzed the data: SM YK HH HY HK IK SK. Contributed reagents/materials/analysis tools: SM KS. Wrote the paper: SM.