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Research Article

Development of Novel Single-Stranded Nucleic Acid Aptamers against the Pro-Angiogenic and Metastatic Enzyme Heparanase (HPSE1)

  • Suzanne C. Simmons,

    Affiliation: Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, Buckinghamshire, United Kingdom

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  • Edward A. McKenzie,

    Affiliation: Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom

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  • Lynda K. Harris,

    Affiliation: Maternal and Fetal Health Research Centre, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom

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  • John D. Aplin,

    Affiliation: Maternal and Fetal Health Research Centre, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom

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  • Paul E. Brenchley,

    Affiliation: Renal Research Group, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom

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  • Maria N. Velasco-Garcia,

    Affiliation: Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, Buckinghamshire, United Kingdom

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  • Sotiris Missailidis mail

    s.missailidis@open.ac.uk

    Affiliation: Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, Buckinghamshire, United Kingdom

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  • Published: June 15, 2012
  • DOI: 10.1371/journal.pone.0037938

About the Authors

Suzanne C. Simmons, Maria N. Velasco-Garcia, Sotiris Missailidis
Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, Buckinghamshire, United Kingdom
Edward A. McKenzie
Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom
Lynda K. Harris, John D. Aplin
Maternal and Fetal Health Research Centre, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom
Paul E. Brenchley
Renal Research Group, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom

Corresponding Author

Email: s.missailidis@open.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SM EM. Performed the experiments: SCS EM LKH MV-G. Analyzed the data: SCS SM EM LKH. Contributed reagents/materials/analysis tools: EM PB JDA LKH. Wrote the paper: SCS SM EM.