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Research Article

Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?

  • Claude Bouchard mail,

    claude.bouchard@pbrc.edu

    Affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • Steven N. Blair,

    Affiliation: Departments of Exercise Science and Epidemiology/Biostatistics, University of South Carolina, Columbia, South Carolina, United States of America

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  • Timothy S. Church,

    Affiliation: Preventive Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • Conrad P. Earnest,

    Affiliation: Preventive Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • James M. Hagberg,

    Affiliation: Department of Kinesiology, University of Maryland, College Park, Maryland, United States of America

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  • Keijo Häkkinen,

    Affiliation: Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland

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  • Nathan T. Jenkins,

    Affiliation: Department of Kinesiology, University of Maryland, College Park, Maryland, United States of America

    Current address: Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, United States of America

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  • Laura Karavirta,

    Affiliation: Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland

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  • William E. Kraus,

    Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Arthur S. Leon,

    Affiliation: School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • D. C. Rao,

    Affiliation: Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Mark A. Sarzynski,

    Affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • James S. Skinner,

    Affiliation: Professor Emeritus of Kinesiology, Indiana University, Bloomington, Indiana, United States of America

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  • Cris A. Slentz,

    Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Tuomo Rankinen

    Affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • Published: May 30, 2012
  • DOI: 10.1371/journal.pone.0037887

About the Authors

Claude Bouchard, Mark A. Sarzynski, Tuomo Rankinen
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
Steven N. Blair
Departments of Exercise Science and Epidemiology/Biostatistics, University of South Carolina, Columbia, South Carolina, United States of America
Timothy S. Church, Conrad P. Earnest
Preventive Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
James M. Hagberg, Nathan T. Jenkins
Department of Kinesiology, University of Maryland, College Park, Maryland, United States of America
Keijo Häkkinen, Laura Karavirta
Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland
William E. Kraus, Cris A. Slentz
Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Arthur S. Leon
School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, United States of America
D. C. Rao
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America
James S. Skinner
Professor Emeritus of Kinesiology, Indiana University, Bloomington, Indiana, United States of America

Corresponding Author

Email: claude.bouchard@pbrc.edu

Competing Interests

C. Bouchard is a member of the Science Advisory Board of Pathway Genomics. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CB TR TSC. Performed the experiments: CB TR. Analyzed the data: CB TR. Contributed reagents/materials/analysis tools: CB SNB TSC CPE JMH KH NTJ LK WEK DCR ASL JSS CAS TR. Wrote the paper: CB. Reviewed and contributed to the final version of the manuscript: CB SNB TSC CPE JMH KH NTJ LK WEK ASL DCR MAS JSS CAS TR.