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Research Article

Evaluation of Allele-Specific Somatic Changes of Genome-Wide Association Study Susceptibility Alleles in Human Colorectal Cancers

  • Madelyn M. Gerber,

    Affiliation: Integrated Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio, United States of America

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  • Heather Hampel,

    Affiliations: The Ohio State University College of Medicine, Columbus, Ohio, United States of America, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America

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  • Nathan P. Schulz,

    Affiliation: The Ohio State University College of Medicine, Columbus, Ohio, United States of America

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  • Soledad Fernandez,

    Affiliation: The Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America

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  • Lai Wei,

    Affiliation: The Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America

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  • Xiao-Ping Zhou,

    Affiliation: Department of Pathology, The Ohio State University, Columbus, Ohio, United States of America

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  • Albert de la Chapelle,

    Affiliations: Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America

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  • Amanda Ewart Toland mail

    Amanda.Toland@osumc.edu

    Affiliations: Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America

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  • Published: May 21, 2012
  • DOI: 10.1371/journal.pone.0037672

About the Authors

Madelyn M. Gerber
Integrated Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio, United States of America
Heather Hampel, Nathan P. Schulz
The Ohio State University College of Medicine, Columbus, Ohio, United States of America
Heather Hampel, Albert de la Chapelle, Amanda Ewart Toland
Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
Heather Hampel, Albert de la Chapelle, Amanda Ewart Toland
Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America
Soledad Fernandez, Lai Wei
The Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America
Xiao-Ping Zhou
Department of Pathology, The Ohio State University, Columbus, Ohio, United States of America
Albert de la Chapelle, Amanda Ewart Toland
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America

Corresponding Author

Email: Amanda.Toland@osumc.edu

Competing Interests

Amanda Toland is a PLoS ONE Editorial Board member. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MMG AET. Performed the experiments: MMG NPS. Analyzed the data: MMG NPS SF LW AET. Contributed reagents/materials/analysis tools: HH XPZ SF LW AdlC NPS AET. Wrote the paper: MMG AET. Edited manuscript: HH XPZ LW SF AdlC NPS.