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Research Article

Interaction of Rio1 Kinase with Toyocamycin Reveals a Conformational Switch That Controls Oligomeric State and Catalytic Activity

  • Irene N. Kiburu,

    Affiliation: Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, and the University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland, College Park, Maryland, United States of America

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  • Nicole LaRonde-LeBlanc mail

    nlaronde@umd.edu

    Affiliation: Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, and the University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland, College Park, Maryland, United States of America

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  • Published: May 22, 2012
  • DOI: 10.1371/journal.pone.0037371

About the Authors

Irene N. Kiburu, Nicole LaRonde-LeBlanc
Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, and the University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland, College Park, Maryland, United States of America

Corresponding Author

Email: nlaronde@umd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: INK NL. Performed the experiments: INK. Analyzed the data: INK NL. Contributed reagents/materials/analysis tools: INK NL. Wrote the paper: INK NL.