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Research Article

Algae-Produced Pfs25 Elicits Antibodies That Inhibit Malaria Transmission

  • James A. Gregory,

    Affiliation: Division of Biological Sciences, and the San Diego Center for Algae Biotechnology, University of California San Diego, California, United States of America

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  • Fengwu Li,

    Affiliation: Division of Infectious Disease, Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Lauren M. Tomosada,

    Affiliation: Division of Biological Sciences, and the San Diego Center for Algae Biotechnology, University of California San Diego, California, United States of America

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  • Chesa J. Cox,

    Affiliation: Division of Biological Sciences, and the San Diego Center for Algae Biotechnology, University of California San Diego, California, United States of America

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  • Aaron B. Topol,

    Affiliation: Division of Biological Sciences, and the San Diego Center for Algae Biotechnology, University of California San Diego, California, United States of America

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  • Joseph M. Vinetz,

    Affiliation: Division of Infectious Disease, Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Stephen Mayfield mail

    smayfield@ucsd.edu

    Affiliation: Division of Biological Sciences, and the San Diego Center for Algae Biotechnology, University of California San Diego, California, United States of America

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  • Published: May 16, 2012
  • DOI: 10.1371/journal.pone.0037179

About the Authors

James A. Gregory, Lauren M. Tomosada, Chesa J. Cox, Aaron B. Topol, Stephen Mayfield
Division of Biological Sciences, and the San Diego Center for Algae Biotechnology, University of California San Diego, California, United States of America
Fengwu Li, Joseph M. Vinetz
Division of Infectious Disease, Department of Medicine, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: smayfield@ucsd.edu

Competing Interests

Stephen Mayfield has a financial interest in Sapphire Energy. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JAG JMV SM. Performed the experiments: JAG LT CC FL AT. Analyzed the data: JAG. Contributed reagents/materials/analysis tools: JAG FL. Wrote the paper: JAG. Constructed and validated algae strains, performed mouse work, CD spectroscopy, immunofluorescence, and microscopy: JAG. Grew and harvested algae: JAG CC. Purified recombinant protein: JAG LT. Performed immunoblots and silver staining: JAG LT CC. Performed ELISAs: JAG AT. Cultured P. falciparum parasites and performed SMFA: FL.