About the Authors
- Navid Shiee
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Affiliations Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America, Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Maryland, United States of America, Neuroradiology Division, Departments of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, United States of America
- Pierre-Louis Bazin
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Affiliation Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
- Kathleen M. Zackowski
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Affiliations Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America
- Sheena K. Farrell
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Affiliation Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America
- Daniel M. Harrison
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Affiliation Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America
- Scott D. Newsome
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Affiliation Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America
- John N. Ratchford
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Affiliation Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America
- Brian S. Caffo
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Affiliation Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
- Peter A. Calabresi
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Affiliation Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America
- Dzung L. Pham
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Affiliations Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America, Neuroradiology Division, Departments of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, United States of America, Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
- Daniel S. Reich
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* E-mail: daniel.reich@nih.gov
Affiliations Neuroradiology Division, Departments of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
Competing Interests
An unrestricted grant from EMD Serono for MRI data acquisition was received for this study. Daniel S. Harrison received fellowship funding from the Partners MS Center of Brigham and Women's Hospital, Boston, MA and research funding from Bayer Schering Pharma. Scott D. Newsome received fellowship funding from the National MS Society (Sylvia Lawry Physician Fellowship) and has received consultant fees from Biogen-IDEC. John N. Ratchford received research support from the Nancy Davis Foundation for MS and support for clinical trials from Novartis, Biogen-Idec, and the University of California-Los Angeles. Brian S. Caffo received funding from Merck Pharmacueticals and Pfizer Pharmaceuticals. Peter A. Calabresi received grants from Biogen-IDEC, Teva, Vertex, Bayer, Genentech, Abbott Labs, and EMD Serono. He received consulting fees from Novartis, Biogen-IDEC, and Teva. There are no patents, products in development, or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: KMZ PAC DSR. Performed the experiments: KMZ SKF DMH SDN JNR PAC DSR. Analyzed the data: NS BSC DSR. Contributed reagents/materials/analysis tools: NS PLB DLP. Wrote the paper: NS DSR.