About the Authors

Masaki Takagi

Affiliations Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan, Department of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan

Tomohiro Ishii

Affiliation Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan

Aileen M. Barnes

Affiliation Bone and Extracellular Matrix Branch, NICHD, NIH, Bethesda, Maryland, United States of America

MaryAnn Weis

Affiliation Orthopaedic Research Laboratories, University of Washington, Seattle, Washington, United States of America

Naoko Amano

Affiliation Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan

Mamoru Tanaka

Affiliation Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan

Ryuji Fukuzawa

Affiliation Department of Pathology and Laboratory Medicine, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan

Gen Nishimura

Affiliation Department of Radiology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan

David R. Eyre

Affiliation Orthopaedic Research Laboratories, University of Washington, Seattle, Washington, United States of America

Joan C. Marini

Affiliation Bone and Extracellular Matrix Branch, NICHD, NIH, Bethesda, Maryland, United States of America

Tomonobu Hasegawa

thaseg@a6.keio.jp

Affiliation Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: M. Takagi DRE JCM TH. Performed the experiments: M. Takagi AMB MW. Analyzed the data: M. Takagi AMB MW RF GN. Contributed reagents/materials/analysis tools: TI NA M. Tanaka. Wrote the paper: M. Takagi JCM TH.