REDD1 Protects Osteoblast Cells from Gamma Radiation-Induced Premature Senescence

Xiang Hong Li; Cam T. Ha; Dadin Fu; Mang Xiao

doi:10.1371/journal.pone.0036604

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Open Access

Peer-reviewed

Research Article

REDD1 Protects Osteoblast Cells from Gamma Radiation-Induced Premature Senescence

Xiang Hong Li,

Affiliation Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Cam T. Ha,

Affiliation Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Dadin Fu,

Affiliation Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Mang Xiao

* E-mail: xiao@afrri.usuhs.mil

Affiliation Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯

REDD1 Protects Osteoblast Cells from Gamma Radiation-Induced Premature Senescence

Xiang Hong Li,
Cam T. Ha,
Dadin Fu,
Mang Xiao

Published: May 18, 2012
https://doi.org/10.1371/journal.pone.0036604

About the Authors

Xiang Hong Li

Affiliation Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Cam T. Ha

Affiliation Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Dadin Fu

Affiliation Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Mang Xiao

* E-mail: xiao@afrri.usuhs.mil

Affiliation Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XHL MX. Performed the experiments: XHL CTH DF MX. Analyzed the data: XHL CTH DF MX. Contributed reagents/materials/analysis tools: XHL CTH DF. Wrote the paper: MX.

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Gamma radiation
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Transfection
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Cellular stress responses
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Apoptosis
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Small interfering RNA
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Cytokines
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Gene expression
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Osteoblasts
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