About the Authors

David Ho

Contributed equally to this work with: David Ho, Li Chen

Affiliation Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America

Li Chen

Contributed equally to this work with: David Ho, Li Chen

Affiliation Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America

Xin Zhao

Affiliation Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America

Nicquanna Durham

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America

Malar Pannirselvam

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America

Dorothy E. Vatner

Affiliation Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America

David J. Morgans

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America

Fady I. Malik

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America

Stephen F. Vatner

vatnersf@umdnj.edu

Affiliations CV Dynamics, Inc., North Brunswick, New Jersey, United States of America, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America

You-Tang Shen

Affiliations CV Dynamics, Inc., North Brunswick, New Jersey, United States of America, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America

Competing Interests

FIM and DJM are employees and stockholders of Cytokinetics, Inc. SFV and YTS are employees and stockholders of CV Dynamics, Inc. Cytokinetics holds the patent of the smooth muscle myosin inhibitor CK-2019165 (U.S. Patent publication 2009-0275537 A1). At the current time, there are no products related to this work in clinical development or on the market to declare. CV Dynamics has no patent rights or financial interest in product development. This does not alter the authors' adherence to the PLoS ONE policies on sharing data and materials as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SFV DH YTS. Performed the experiments: DH LC YTS XZ ND MP. Analyzed the data: SFV DH LC YTS DEV ND MP. Contributed reagents/materials/analysis tools: FIM DJM ND MP. Wrote the paper: DH SVF DEV.