Advertisement
Research Article

Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device

  • Brian J. Kirby mail,

    bk88@cornell.edu (BJK); pag2015@med.cornell.edu (PG)

    Affiliations: Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, United States of America, Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

    X
  • Mona Jodari,

    Affiliation: Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

    X
  • Matthew S. Loftus,

    Affiliation: Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

    X
  • Gunjan Gakhar,

    Affiliation: Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

    X
  • Erica D. Pratt,

    Affiliations: Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, United States of America, Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

    X
  • Chantal Chanel-Vos,

    Affiliation: Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

    X
  • Jason P. Gleghorn,

    Affiliations: Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, United States of America, Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

    X
  • Steven M. Santana,

    Affiliations: Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, United States of America, Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

    X
  • He Liu,

    Affiliation: Department of Urology, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

    X
  • James P. Smith,

    Affiliations: Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, United States of America, Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

    X
  • Vicente N. Navarro,

    Affiliation: Department of Urology, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

    X
  • Scott T. Tagawa,

    Affiliation: Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

    X
  • Neil H. Bander,

    Affiliation: Department of Urology, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

    X
  • David M. Nanus,

    Affiliations: Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America, Department of Urology, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

    X
  • Paraskevi Giannakakou mail

    bk88@cornell.edu (BJK); pag2015@med.cornell.edu (PG)

    Affiliation: Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

    X
  • Published: April 27, 2012
  • DOI: 10.1371/journal.pone.0035976

About the Authors

Brian J. Kirby, Erica D. Pratt, Jason P. Gleghorn, Steven M. Santana, James P. Smith
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, United States of America
Brian J. Kirby, Erica D. Pratt, Jason P. Gleghorn, Steven M. Santana, James P. Smith
Biomedical Engineering, Cornell University, Ithaca, New York, United States of America
Mona Jodari, Matthew S. Loftus, Gunjan Gakhar, Chantal Chanel-Vos, Scott T. Tagawa, David M. Nanus, Paraskevi Giannakakou
Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America
He Liu, Vicente N. Navarro, Neil H. Bander, David M. Nanus
Department of Urology, Weill Cornell Medical College and New York Presbyterian Hospital, New York, New York, United States of America

Corresponding Authors

Competing Interests

BK, PG, ST and DN disclose consulting income from Sanofi US. This does not alter our adherence to all the Plos One's policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BK DN ST PG JGEP SS JS ML MJ GG. Performed the experiments: VN CCV. Analyzed the data: BK DN ST PG JGEP SS JS ML MJ GG. Contributed reagents/materials/analysis tools: SS EP NB HL. Wrote the paper: BK DN PG.