About the Authors

Stefanie Galbán

Affiliation Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of America

Benjamin Lemasson

Affiliation Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America

Terence M. Williams

Affiliation Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of America

Fei Li

Affiliation Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America

Kevin A. Heist

Affiliation Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America

Timothy D. Johnson

Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Judith S. Leopold

Affiliation Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of America

Thomas L. Chenevert

Affiliation Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of America

Theodore S. Lawrence

Affiliation Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America

Alnawaz Rehemtulla

Affiliations Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America

Tom Mikkelsen

Affiliation Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, Michigan, United States of America

Eric C. Holland

Affiliation Departments of Cancer Biology and Genetics and Neurosurgery, and Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Craig J. Galbán

Affiliation Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America

Brian D. Ross

bdross@umich.edu

Affiliation Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts. BDR and AR have ownership interest (including patents) from ImBio, LLC. BDR, AR, TLC and CJG have a financial interest in the underlying DW-MRI technology. The DW-MRI technology was patented by the University of Michigan. These patents were licensed to a small company, ImBio, in which BDR and AR, co-authors on this manuscript have a partial ownership through shares in the company. The patent names and numbers relating to ImBio, LLC: 1) Imaging system, computer, program product and method for detecting changes in rates of water diffusion in a tissue using magnetic resonance imaging (MRI)(6,567,684). 2) Systems and methods for tissue imaging (20090035218). There are no products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: BDR AR SG TSL TLC. Performed the experiments: BL FL KAH. Analyzed the data: CJG TMW TDJ. Contributed reagents/materials/analysis tools: ECH. Wrote the paper: SG BDR JSL TM.