About the Authors

Balajee R. Somalinga

philip.thomas@utsouthwestern.edu (PJT); balajee.somalinga@utsouthwestern.edu (BRS)

Affiliation Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Cameron E. Day

Affiliation Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Shuguang Wei

Affiliation Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Michael G. Roth

Affiliation Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Philip J. Thomas

philip.thomas@utsouthwestern.edu (PJT); balajee.somalinga@utsouthwestern.edu (BRS)

Affiliation Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Competing Interests

Philip J. Thomas is a founder and Scientific Advisory Board Member of Reata Pharmaceuticals. He holds shares of Reata common stock. Reata has a sponsored research agreement with the University of Texas that supports work in Phillip J. Thomas' laboratory. Reata has licensed the beta galactosidase assay from the University of Texas Board of Reagent (Patent holders) for small molecule discovery. The license does not restrict the use of or distribution of the assay for research purposes. Patents: U.S. Patent Number: 7,635,569 Patent Title: Protein/Solubility Folding Assessed by Structural Complementation. Inventors: Thomas, Philip J.; Hunt, John F.; Wigley, William C., Stidham, Rhesa D. Issued: 12/22/09 U.S. Patent Number: 7,455,978 Patent Title: Protein/Solubility Folding Assessed by Structural Complementation. Inventors: Thomas, Philip J.; Hunt, John F.; Wigley, William C.; Stidham, Rhesa D. Issued: 11/25/08 U.S. Patent Number: 6,727,070 Patent Title: Protein/Solubility Folding Assessed by Structural Complementation. Inventors: Thomas, Philip J.; Hunt, John F.; Wigley, William C.; Stidham, Rhesa D. Issued: 04/27/04 This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BRS PJT. Performed the experiments: BRS CED. Analyzed the data: BRS PJT. Contributed reagents/materials/analysis tools: BRS SW MGR PJT. Wrote the paper: BRS PJT.