About the Authors

Surbhi Jain

Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

Sitong Chen

Contributed equally to this work with: Sitong Chen, Kung-Chao Chang, Yih-Jyh Lin, Chi-Tan Hu

Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

Kung-Chao Chang

Contributed equally to this work with: Sitong Chen, Kung-Chao Chang, Yih-Jyh Lin, Chi-Tan Hu

Affiliation Department of Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China

Yih-Jyh Lin

Contributed equally to this work with: Sitong Chen, Kung-Chao Chang, Yih-Jyh Lin, Chi-Tan Hu

Affiliation Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China

Chi-Tan Hu

Contributed equally to this work with: Sitong Chen, Kung-Chao Chang, Yih-Jyh Lin, Chi-Tan Hu

Affiliation Department of Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan, Republic of China

Batbold Boldbaatar

Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

James P. Hamilton

Affiliation Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Selena Y. Lin

Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

Ting-Tsung Chang

Affiliation Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China

Shun-Hua Chen

Affiliation Department of Microbiology, Medical College, National Cheng Kung University, Tainan, Taiwan, Republic of China

Wei Song

Affiliation JBS Science Inc., Doylestown, Pennsylvania, United States of America

Stephen J. Meltzer

Affiliations Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States of America

Timothy M. Block

Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

Ying-Hsiu Su

Ying-hsiu.Su@drexelmed.edu

Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have the following competing interest: Wei Song is employed by a commercial company, JBS Science Inc.,Doylestown, PA. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YHS SJ. Performed the experiments: SJ SC BB SYL. Analyzed the data: SJ YHS SC WS. Contributed reagents/materials/analysis tools: CTH JPH TTC KCC SHC SJM YJL. Wrote the paper: SJ YHS TMB.