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Research Article

Learning Transcriptional Regulatory Relationships Using Sparse Graphical Models

  • Xiang Zhang equal contributor,

    equal contributor Contributed equally to this work with: Xiang Zhang, Wei Cheng

    Affiliations: Microsoft Research, Los Angeles, California, United States of America, Case Western Reserve University, Cleveland, Ohio, United States of America, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Wei Cheng equal contributor,

    equal contributor Contributed equally to this work with: Xiang Zhang, Wei Cheng

    Affiliation: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Jennifer Listgarten,

    Affiliation: Microsoft Research, Los Angeles, California, United States of America

    X
  • Carl Kadie,

    Affiliation: Microsoft Research, Los Angeles, California, United States of America

    X
  • Shunping Huang,

    Affiliation: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Wei Wang,

    Affiliation: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • David Heckerman mail

    heckerma@microsoft.com

    Affiliation: Microsoft Research, Los Angeles, California, United States of America

    X
  • Published: May 07, 2012
  • DOI: 10.1371/journal.pone.0035762

About the Authors

Xiang Zhang, Jennifer Listgarten, Carl Kadie, David Heckerman
Microsoft Research, Los Angeles, California, United States of America
Xiang Zhang
Case Western Reserve University, Cleveland, Ohio, United States of America
Xiang Zhang, Wei Cheng, Shunping Huang, Wei Wang
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: heckerma@microsoft.com

Competing Interests

The authors have read the journal's policy and have the following conflicts: David Heckerman, Jennifer Listgarten, and Carl Kadie are with Microsoft Research. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: XZ DH. Performed the experiments: XZ WC SH DH. Analyzed the data: XZ WC JL DH. Contributed reagents/materials/analysis tools: CK. Wrote the paper: XZ WC WW DH.