Advertisement
Research Article

The Adult Human Brain Harbors Multipotent Perivascular Mesenchymal Stem Cells

  • Gesine Paul equal contributor mail,

    equal contributor Contributed equally to this work with: Gesine Paul, Ilknur Özen

    gesine.paul@med.lu.se

    Affiliations: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden, Department of Neurology, Scania University Hospital, Lund, Sweden, Translational Neurology Group, Department of Clinical Sciences, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    X
  • Ilknur Özen equal contributor,

    equal contributor Contributed equally to this work with: Gesine Paul, Ilknur Özen

    Affiliations: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden, Translational Neurology Group, Department of Clinical Sciences, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    X
  • Nicolaj S. Christophersen,

    Affiliation: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    X
  • Thomas Reinbothe,

    Affiliation: Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden

    X
  • Johan Bengzon,

    Affiliation: Department of Neurosurgery, Scania University Hospital and Lund Stem Cell Center, Lund University, Lund, Sweden

    X
  • Edward Visse,

    Affiliation: The Rausing Laboratory, Department of Clinical Medicine, Lund University, Lund, Sweden

    X
  • Katarina Jansson,

    Affiliation: NeuroNova AB, Stockholm, Sweden

    X
  • Karin Dannaeus,

    Affiliation: NeuroNova AB, Stockholm, Sweden

    X
  • Catarina Henriques-Oliveira,

    Affiliation: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    X
  • Laurent Roybon,

    Affiliation: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    X
  • Sergey V. Anisimov,

    Affiliation: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    X
  • Erik Renström,

    Affiliation: Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden

    X
  • Mikael Svensson,

    Affiliation: Department of Neurosurgery, Karolinska Hospital, Stockholm, Sweden

    X
  • Anders Haegerstrand,

    Affiliation: NeuroNova AB, Stockholm, Sweden

    X
  • Patrik Brundin

    Affiliations: Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • Published: April 16, 2012
  • DOI: 10.1371/journal.pone.0035577

About the Authors

Gesine Paul, Ilknur Özen, Nicolaj S. Christophersen, Catarina Henriques-Oliveira, Laurent Roybon, Sergey V. Anisimov, Patrik Brundin
Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
Gesine Paul
Department of Neurology, Scania University Hospital, Lund, Sweden
Thomas Reinbothe, Erik Renström
Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden
Johan Bengzon
Department of Neurosurgery, Scania University Hospital and Lund Stem Cell Center, Lund University, Lund, Sweden
Edward Visse
The Rausing Laboratory, Department of Clinical Medicine, Lund University, Lund, Sweden
Katarina Jansson, Karin Dannaeus, Anders Haegerstrand
NeuroNova AB, Stockholm, Sweden
Mikael Svensson
Department of Neurosurgery, Karolinska Hospital, Stockholm, Sweden
Gesine Paul, Ilknur Özen
Translational Neurology Group, Department of Clinical Sciences, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
Patrik Brundin
Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

Corresponding Author

Email: gesine.paul@med.lu.se

Competing Interests

The following co-authors are full-time employees of NeuroNova AB: K.D., K.J. and A.H. NeuroNova AB is a small Swedish biopharmaceutical company pursuing clinical trials in Parkinson's disease and Amyotrophic Lateral Sclerosis (www.neuronova.com). The company has a general interest in understanding the regenerative capacity of the adult brain but is not pursuing strategies related to commercialization of cultured stem cells or therapies based on stem cell/progenitor transplantation. The company has not sponsored the work performed at the academic institutions. The company employees being co-authors on the manuscript have not been influenced by commercial interest interpreting the data. The authors being employees at NeuroNova AB does also not alter the authors' adherence to all PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GP IÖ AH PB KJ KD. Performed the experiments: GP IÖ TR SA NSC LR CHO KJ KD. Analyzed the data: GP IÖ TR NSC EV AH PB ER. Contributed reagents/materials/analysis tools: JB MS. Wrote the paper: GP IÖ EV PB JB.