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Research Article

The Influence of Spin-Labeled Fluorene Compounds on the Assembly and Toxicity of the Aβ Peptide

  • Jitka Petrlova,

    Affiliation: Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, United States of America

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  • Tamás Kálai,

    Affiliation: Institute of Organic and Medicinal Chemistry, University of Pécs, Pécs, Hungary

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  • Izumi Maezawa,

    Affiliation: Laboratory Medicine, Department of Pathology, M.I.N.D. Institute, Miami University, Oxford, Ohio, United States of America

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  • Robin Altman,

    Affiliation: Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, United States of America

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  • Ghimire Harishchandra,

    Affiliation: Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio, United States of America

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  • Hyun-Seok Hong,

    Affiliation: Laboratory Medicine, Department of Pathology, M.I.N.D. Institute, Miami University, Oxford, Ohio, United States of America

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  • Daniel A. Bricarello,

    Affiliation: Department of Applied Science, University of California Davis, Davis, California, United States of America

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  • Atul N. Parikh,

    Affiliation: Department of Applied Science, University of California Davis, Davis, California, United States of America

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  • Gary A. Lorigan,

    Affiliation: Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio, United States of America

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  • Lee-Way Jin,

    Affiliation: Laboratory Medicine, Department of Pathology, M.I.N.D. Institute, Miami University, Oxford, Ohio, United States of America

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  • Kálmán Hideg,

    Affiliation: Institute of Organic and Medicinal Chemistry, University of Pécs, Pécs, Hungary

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  • John C. Voss mail

    jcvoss@ucdavis.edu

    Affiliation: Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, United States of America

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  • Published: April 30, 2012
  • DOI: 10.1371/journal.pone.0035443

About the Authors

Jitka Petrlova, Robin Altman, John C. Voss
Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, United States of America
Tamás Kálai, Kálmán Hideg
Institute of Organic and Medicinal Chemistry, University of Pécs, Pécs, Hungary
Izumi Maezawa, Hyun-Seok Hong, Lee-Way Jin
Laboratory Medicine, Department of Pathology, M.I.N.D. Institute, Miami University, Oxford, Ohio, United States of America
Ghimire Harishchandra, Gary A. Lorigan
Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio, United States of America
Daniel A. Bricarello, Atul N. Parikh
Department of Applied Science, University of California Davis, Davis, California, United States of America

Corresponding Author

Email: jcvoss@ucdavis.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JCV KH LWJ. Performed the experiments: JP RA IM HSH DAB. Analyzed the data: JCV JP LWJ. Contributed reagents/materials/analysis tools: TK KH LWJ GAL GH ANP. Wrote the paper: JP RA JCV.