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Research Article

Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

  • Justin Y. Kwan mail,

    kwanjy@ninds.nih.gov

    Affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Suh Young Jeong,

    Affiliation: Molecular Medicine Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Peter Van Gelderen,

    Affiliation: Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Han-Xiang Deng,

    Affiliation: Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Martha M. Quezado,

    Affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Laura E. Danielian,

    Affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • John A. Butman,

    Affiliation: Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Lingye Chen,

    Affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Elham Bayat,

    Affiliation: Department of Neurology, George Washington University, Washington, D. C., United States of America

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  • James Russell,

    Affiliation: Department of Neurology, University of Maryland, Baltimore, Maryland, United States of America

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  • Teepu Siddique,

    Affiliation: Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Jeff H. Duyn,

    Affiliation: Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Tracey A. Rouault,

    Affiliation: Molecular Medicine Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Mary Kay Floeter

    Affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: April 17, 2012
  • DOI: 10.1371/journal.pone.0035241

About the Authors

Justin Y. Kwan, Laura E. Danielian, Lingye Chen, Mary Kay Floeter
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
Suh Young Jeong, Tracey A. Rouault
Molecular Medicine Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
Peter Van Gelderen, Jeff H. Duyn
Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
Han-Xiang Deng, Teepu Siddique
Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
Martha M. Quezado
National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
John A. Butman
Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America
Elham Bayat
Department of Neurology, George Washington University, Washington, D. C., United States of America
James Russell
Department of Neurology, University of Maryland, Baltimore, Maryland, United States of America

Corresponding Author

Email: kwanjy@ninds.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JYK PVG LED JAB JHD MKF. Performed the experiments: JYK SJ PVG HD LED LC MMQ EB JR TS. Analyzed the data: JYK SJ PVG HD LED JAB LC TS JHD TAR MKF. Contributed reagents/materials/analysis tools: MKF PVG JHD TAR HD TS. Wrote the paper: JYK LED MKF JHD JAB SJ. Pathology evaluation: MMQ. Clinical evaluation: JYK MKF JR EB.