Optimal Design of Intervention Studies to Prevent Influenza in Healthy Cohorts

Brendan Klick; Hiroshi Nishiura; Benjamin J. Cowling

doi:10.1371/journal.pone.0035166

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Open Access

Peer-reviewed

Research Article

Optimal Design of Intervention Studies to Prevent Influenza in Healthy Cohorts

Brendan Klick,

Affiliation Infectious Disease Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China
⨯
Hiroshi Nishiura,

Affiliations Infectious Disease Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China, PRESTO, Japan Science and Technology Agency, Saitama, Japan
⨯
Benjamin J. Cowling

* E-mail: bcowling@hku.hk

Affiliation Infectious Disease Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China
⨯

Optimal Design of Intervention Studies to Prevent Influenza in Healthy Cohorts

Brendan Klick,
Hiroshi Nishiura,
Benjamin J. Cowling

Published: April 13, 2012
https://doi.org/10.1371/journal.pone.0035166

About the Authors

Brendan Klick

Affiliation Infectious Disease Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China

Hiroshi Nishiura

Affiliations Infectious Disease Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China, PRESTO, Japan Science and Technology Agency, Saitama, Japan

Benjamin J. Cowling

* E-mail: bcowling@hku.hk

Competing Interests

BJC has received study funding from MedImmune Inc., a manufacturer of influenza vaccines. The authors report no other potential conflicts of interest. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BK BJC. Performed the experiments: BK. Analyzed the data: BK. Wrote the paper: BK HN BJC.

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Influenza
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Reverse transcriptase-polymerase chain reaction
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Respiratory infections
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Serology
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Influenza viruses
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Cohort studies
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Epidemiology
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Infectious disease epidemiology
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