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Research Article

Docosahexaenoic Acid Inhibits Helicobacter pylori Growth In Vitro and Mice Gastric Mucosa Colonization

  • Marta Correia,

    Affiliations: Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal, Faculty of Medicine, University of Porto, Porto, Portugal, Unité de Pathogenèse de Helicobacter, Institut Pasteur, Paris, France

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  • Valérie Michel,

    Affiliation: Unité de Pathogenèse de Helicobacter, Institut Pasteur, Paris, France

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  • António A. Matos,

    Affiliations: Serviço de Microscopia Electrónica, Hospital Curry Cabral, Lisboa, Portugal, Centre for Environmental and Marine Studies (CESAM), Aveiro University, Aveiro, Portugal

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  • Patrícia Carvalho,

    Affiliations: Serviço de Microscopia Electrónica, Hospital Curry Cabral, Lisboa, Portugal, Centre for Environmental and Marine Studies (CESAM), Aveiro University, Aveiro, Portugal

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  • Maria J. Oliveira,

    Affiliation: Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal

    Current address: Instituto Nacional Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal

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  • Rui M. Ferreira,

    Affiliations: Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal, Faculty of Medicine, University of Porto, Porto, Portugal

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  • Marie-Agnès Dillies,

    Affiliation: Plate-forme Transcriptome et Epigénome, Génopole Institut Pasteur, Paris, France

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  • Michel Huerre,

    Affiliation: Unité de Recherche et d'Expertise en Histotechnologie et Pathologie, Institut Pasteur, Paris, France

    Current address: Institut Curie, Paris, France

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  • Raquel Seruca,

    Affiliations: Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal, Faculty of Medicine, University of Porto, Porto, Portugal

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  • Ceu Figueiredo,

    Affiliations: Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal, Faculty of Medicine, University of Porto, Porto, Portugal

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  • Jose C. Machado mail,

    josem@ipatimup.pt (JCM); etouati@pasteur.fr (ET)

    Affiliations: Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal, Faculty of Medicine, University of Porto, Porto, Portugal

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  • Eliette Touati mail

    josem@ipatimup.pt (JCM); etouati@pasteur.fr (ET)

    Affiliation: Unité de Pathogenèse de Helicobacter, Institut Pasteur, Paris, France

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  • Published: April 17, 2012
  • DOI: 10.1371/journal.pone.0035072

About the Authors

Marta Correia, Maria J. Oliveira, Rui M. Ferreira, Raquel Seruca, Ceu Figueiredo, Jose C. Machado
Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
Marta Correia, Rui M. Ferreira, Raquel Seruca, Ceu Figueiredo, Jose C. Machado
Faculty of Medicine, University of Porto, Porto, Portugal
Marta Correia, Valérie Michel, Eliette Touati
Unité de Pathogenèse de Helicobacter, Institut Pasteur, Paris, France
António A. Matos, Patrícia Carvalho
Serviço de Microscopia Electrónica, Hospital Curry Cabral, Lisboa, Portugal
Marie-Agnès Dillies
Plate-forme Transcriptome et Epigénome, Génopole Institut Pasteur, Paris, France
Michel Huerre
Unité de Recherche et d'Expertise en Histotechnologie et Pathologie, Institut Pasteur, Paris, France
António A. Matos, Patrícia Carvalho
Centre for Environmental and Marine Studies (CESAM), Aveiro University, Aveiro, Portugal

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MC JCM ET. Performed the experiments: MC VM AAM ET PC. Analyzed the data: MC AAM MJO MH JCM ET MD. Contributed reagents/materials/analysis tools: AAM RMF RS CF. Wrote the paper: MC JCM ET.