A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex

Hsin-Chou Yang; Lun-Ching Chang; Yu-Jen Liang; Chien-Hsing Lin; Pei-Li Wang

doi:10.1371/journal.pone.0034840

Loading metrics

Open Access

Peer-reviewed

Research Article

A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex

Hsin-Chou Yang ,

* E-mail: hsinchou@stat.sinica.edu.tw

Affiliation Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
⨯
Lun-Ching Chang,

Affiliation Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
⨯
Yu-Jen Liang,

Affiliations Institute of Statistical Science, Academia Sinica, Taipei, Taiwan, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
⨯
Chien-Hsing Lin,

Affiliation Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County, Taiwan
⨯
Pei-Li Wang

Affiliation Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
⨯

A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex

Hsin-Chou Yang,
Lun-Ching Chang,
Yu-Jen Liang,
Chien-Hsing Lin,
Pei-Li Wang

Published: April 20, 2012
https://doi.org/10.1371/journal.pone.0034840

About the Authors

Hsin-Chou Yang

* E-mail: hsinchou@stat.sinica.edu.tw

Affiliation Institute of Statistical Science, Academia Sinica, Taipei, Taiwan

Lun-Ching Chang

Affiliation Institute of Statistical Science, Academia Sinica, Taipei, Taiwan

Yu-Jen Liang

Affiliations Institute of Statistical Science, Academia Sinica, Taipei, Taiwan, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

Chien-Hsing Lin

Affiliation Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County, Taiwan

Pei-Li Wang

Affiliation Institute of Statistical Science, Academia Sinica, Taipei, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HCY. Analyzed the data: HCY LCC YJL CHL PLW. Contributed reagents/materials/analysis tools: HCY. Wrote the paper: HCY.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Homozygosity
Is the Subject Area "Homozygosity" applicable to this article?

Thanks for your feedback.
Single nucleotide polymorphisms
Is the Subject Area "Single nucleotide polymorphisms" applicable to this article?

Thanks for your feedback.
Rheumatoid arthritis
Is the Subject Area "Rheumatoid arthritis" applicable to this article?

Thanks for your feedback.
Genome-wide association studies
Is the Subject Area "Genome-wide association studies" applicable to this article?

Thanks for your feedback.
Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.
Major histocompatibility complex
Is the Subject Area "Major histocompatibility complex" applicable to this article?

Thanks for your feedback.
Computer software
Is the Subject Area "Computer software" applicable to this article?

Thanks for your feedback.
Gene mapping
Is the Subject Area "Gene mapping" applicable to this article?

Thanks for your feedback.