About the Authors

Janice Pogue

Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

janice.pogue@phri.ca

Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

P. J. Devereaux

Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

Lehana Thabane

Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

Affiliation Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

Salim Yusuf

Contributed equally to this work with: Janice Pogue, P. J. Devereaux, Lehana Thabane, Salim Yusuf

Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

Competing Interests

AstraZeneca provided the study drug for the POISE study, which is used as an example in this methodology manuscript, but the primary source of funds was the Canadian Institutes of Health Research. AstraZeneca has never had any influence over the publication or presentation of data from the POISE study. Salim Yusuf received consultancy fees, research grants and honoraria from AstraZeneca. Other authors have no conflict of interest. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JP PD SY. Performed the experiments: JP PD SY. Analyzed the data: JP. Wrote the paper: JP LT PD SY.