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Research Article

A Biomechanical Analysis of Ventral Furrow Formation in the Drosophila Melanogaster Embryo

  • Vito Conte,

    Affiliation: Institute for Bioengineering of Catalonia, Barcelona, Spain

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  • Florian Ulrich,

    Affiliation: Skirball Institute of Biomolecular Medicine, New York Hospital, New York, New York, United States of America

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  • Buzz Baum,

    Affiliation: Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, United Kingdom

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  • Jose Muñoz,

    Affiliation: Laboratori de Càlcul Numèric, Department of Applied Mathematics III, Universitat Politècnica de Catalunya, Barcelona, Spain

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  • Jim Veldhuis,

    Affiliation: Department of Civil and Environmental Engineering, University of Waterloo, Waterloo, Canada

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  • Wayne Brodland,

    Affiliations: Department of Civil and Environmental Engineering, University of Waterloo, Waterloo, Canada, Department of Biology, University of Waterloo, Waterloo, Canada

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  • Mark Miodownik mail

    m.miodownik@ucl.ac.uk

    Affiliation: Mechanical Engineering Department, University College London, London, United Kingdom

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  • Published: April 12, 2012
  • DOI: 10.1371/journal.pone.0034473

About the Authors

Vito Conte
Institute for Bioengineering of Catalonia, Barcelona, Spain
Florian Ulrich
Skirball Institute of Biomolecular Medicine, New York Hospital, New York, New York, United States of America
Buzz Baum
Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, United Kingdom
Jose Muñoz
Laboratori de Càlcul Numèric, Department of Applied Mathematics III, Universitat Politècnica de Catalunya, Barcelona, Spain
Jim Veldhuis, Wayne Brodland
Department of Civil and Environmental Engineering, University of Waterloo, Waterloo, Canada
Wayne Brodland
Department of Biology, University of Waterloo, Waterloo, Canada
Mark Miodownik
Mechanical Engineering Department, University College London, London, United Kingdom

Corresponding Author

Email: m.miodownik@ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MM WB BB. Performed the experiments: FU BB VC JV. Analyzed the data: VC JM MM GWB BB. Contributed reagents/materials/analysis tools: FU JV VC. Wrote the paper: MM GWB VC.