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Research Article

Functional Validation of Hydrophobic Adaptation to Physiological Temperature in the Small Heat Shock Protein αA-crystallin

  • Mason Posner mail,

    mposner@ashland.edu

    Affiliation: Department of Biology, Ashland University, Ashland, Ohio, United States of America

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  • Andor J. Kiss,

    Affiliation: Department of Zoology, Miami University, Oxford, Ohio, United States of America

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  • Jackie Skiba,

    Affiliation: Department of Biology, Ashland University, Ashland, Ohio, United States of America

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  • Amy Drossman,

    Affiliation: Department of Biology, Ashland University, Ashland, Ohio, United States of America

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  • Monika B. Dolinska,

    Affiliation: Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • J. Fielding Hejtmancik,

    Affiliation: Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Yuri V. Sergeev

    Affiliation: Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pone.0034438

About the Authors

Mason Posner, Jackie Skiba, Amy Drossman
Department of Biology, Ashland University, Ashland, Ohio, United States of America
Andor J. Kiss
Department of Zoology, Miami University, Oxford, Ohio, United States of America
Monika B. Dolinska, J. Fielding Hejtmancik, Yuri V. Sergeev
Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: mposner@ashland.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MP JS AD AJK JFH YVS. Performed the experiments: MP JS AD AJK MD YVS. Analyzed the data: MP JS AD AJK MD YVS. Contributed reagents/materials/analysis tools: MP AJK JFH YVS. Wrote the paper: MP JS AD AJK JFH YVS.