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Research Article

Cryptic Distant Relatives Are Common in Both Isolated and Cosmopolitan Genetic Samples

  • Brenna M. Henn equal contributor mail,

    equal contributor Contributed equally to this work with: Brenna M. Henn, Lawrence Hon

    bmhenn@stanford.edu (BMH); joanna@23andme.com (JLM)

    Affiliations: 23andMe, Inc., Mountain View, California, United States of America, Department of Genetics, Stanford University, Stanford, California, United States of America

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  • Lawrence Hon equal contributor,

    equal contributor Contributed equally to this work with: Brenna M. Henn, Lawrence Hon

    Affiliation: 23andMe, Inc., Mountain View, California, United States of America

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  • J. Michael Macpherson,

    Affiliation: 23andMe, Inc., Mountain View, California, United States of America

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  • Nick Eriksson,

    Affiliation: 23andMe, Inc., Mountain View, California, United States of America

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  • Serge Saxonov,

    Affiliation: 23andMe, Inc., Mountain View, California, United States of America

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  • Itsik Pe'er,

    Affiliation: Department of Computer Science, Columbia University, New York, New York, United States of America

    X
  • Joanna L. Mountain mail

    bmhenn@stanford.edu (BMH); joanna@23andme.com (JLM)

    Affiliation: 23andMe, Inc., Mountain View, California, United States of America

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  • Published: April 03, 2012
  • DOI: 10.1371/journal.pone.0034267

About the Authors

Brenna M. Henn, Lawrence Hon, J. Michael Macpherson, Nick Eriksson, Serge Saxonov, Joanna L. Mountain
23andMe, Inc., Mountain View, California, United States of America
Brenna M. Henn
Department of Genetics, Stanford University, Stanford, California, United States of America
Itsik Pe'er
Department of Computer Science, Columbia University, New York, New York, United States of America

Corresponding Authors

Competing Interests

BMH, LH, JMM, NE, SS, and JLM are or were previously employed by 23andMe and own stock options in the company. The research described in this paper is related to a web site feature developed by 23andMe. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. However, the authors' obligations to protect their customers' privacy (as outlined in our Terms of Service and Privacy Statement) prevent them from making their customers' individual-level data publicly available. Aggregate-level data (for example, in the form of tables that were used for the authors' statistics) can be made available upon request. This research was designed by the 23andMe, Inc. research team and funded by 23andMe, Inc. (www.23andme.com/research). There are no current external funding sources for this study. 23andMe, Inc. non-research staff had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author Contributions

Conceived and designed the experiments: LH JLM IP BMH. Performed the experiments: LH. Analyzed the data: LH. Contributed reagents/materials/analysis tools: JMM SS NE. Wrote the paper: BMH LH JLM IP.