About the Authors
- Jonathan Z. Li
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* E-mail: Jli22@partners.org
Affiliations Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
- Chanson J. Brumme
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Affiliation Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America
- Michael M. Lederman
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Affiliation Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America
- Zabrina L. Brumme
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Affiliations Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America, Simon Fraser University, Burnaby, British Columbia, Canada
- Hongying Wang
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Affiliation Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts, United States of America
- John Spritzler
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Affiliation Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts, United States of America
- Mary Carrington
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Affiliations Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America, Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI Frederick, Frederick, Maryland, United States of America
- Kathleen Medvik
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Affiliation Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America
- Bruce D. Walker
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Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
- Robert T. Schooley
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Affiliation Division of Infectious Diseases, University of California San Diego, La Jolla, California, United States of America
- Daniel R. Kuritzkes
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Affiliations Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
- for the AIDS Clinical Trials Group A5197 Study Team
Competing Interests
The authors have the following competing interests: Drs. Kuritzkes, Lederman, and Schooley are consultants to Merck; Dr. Kuritzkes has received research support from Merck. Mary Carrington is an employee of SAIC-Frederick, Inc. Dr. Li is the recipient of a Clinical Investigator Training Program Fellowship: Harvard/MIT Health Sciences and Technology - Beth Israel Deaconess Medical Center, in collaboration with Pfizer Inc. and Merck & Co. The authors appreciate Dr. Michael Robertson's (Merck Research Laboratories) input in the design of the study and review of the manuscript. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: JZL MML ZLB DRK. Performed the experiments: JZL CJB MML MC KM. Analyzed the data: JZL CJB ZLB HW JS. Contributed reagents/materials/analysis tools: MML MNR MC BDW RTS DRK. Wrote the paper: JZL CJB MML ZLB HW JS MNR MC RTS DRK.