Treatment of Mouse Limb Ischemia with an Integrative Hypoxia-Responsive Vector Expressing the Vascular Endothelial Growth Factor Gene

Eduardo Gallatti Yasumura; Roberta Sessa Stilhano; Vívian Yochiko Samoto; Priscila Keiko Matsumoto; Leonardo Pinto de Carvalho; Valderez Bastos Valero Lapchik; Sang Won Han

doi:10.1371/journal.pone.0033944

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Open Access

Peer-reviewed

Research Article

Treatment of Mouse Limb Ischemia with an Integrative Hypoxia-Responsive Vector Expressing the Vascular Endothelial Growth Factor Gene

Eduardo Gallatti Yasumura,
Roberta Sessa Stilhano,
Vívian Yochiko Samoto,
Priscila Keiko Matsumoto,
Leonardo Pinto de Carvalho,
Valderez Bastos Valero Lapchik,
Sang Won Han

* E-mail: sang.han@unifesp.br

Affiliation Research Center for Gene Therapy, Department of Biophysics, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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Treatment of Mouse Limb Ischemia with an Integrative Hypoxia-Responsive Vector Expressing the Vascular Endothelial Growth Factor Gene

Eduardo Gallatti Yasumura,
Roberta Sessa Stilhano,
Vívian Yochiko Samoto,
Priscila Keiko Matsumoto,
Leonardo Pinto de Carvalho,
Valderez Bastos Valero Lapchik,
Sang Won Han

Published: March 21, 2012
https://doi.org/10.1371/journal.pone.0033944

About the Authors

Eduardo Gallatti Yasumura

Roberta Sessa Stilhano

Vívian Yochiko Samoto

Priscila Keiko Matsumoto

Leonardo Pinto de Carvalho

Valderez Bastos Valero Lapchik

Sang Won Han

* E-mail: sang.han@unifesp.br

Affiliation Research Center for Gene Therapy, Department of Biophysics, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SWH. Performed the experiments: EGY RSS VYS PKM LPC VBVL. Analyzed the data: EGY RSS VYS PKM LPC VBVL SWH. Contributed reagents/materials/analysis tools: VBVL SWH. Wrote the paper: EGY SWH.

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Gene expression
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Transfection
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Necrosis
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Body limbs
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Ischemia
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Gene therapy
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Medical hypoxia
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Hypoxia
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