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Research Article

Increase in Muscle Mitochondrial Biogenesis Does Not Prevent Muscle Loss but Increased Tumor Size in a Mouse Model of Acute Cancer-Induced Cachexia

  • Xiao Wang,

    Affiliation: The Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Alicia M. Pickrell,

    Affiliation: Neuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Teresa A. Zimmers,

    Affiliations: The Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America

    Current address: of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Carlos T. Moraes mail

    cmoraes@med.miami.edu

    Affiliations: The Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Neuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Published: March 12, 2012
  • DOI: 10.1371/journal.pone.0033426

About the Authors

Xiao Wang, Teresa A. Zimmers, Carlos T. Moraes
The Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
Alicia M. Pickrell, Carlos T. Moraes
Neuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, Florida, United States of America
Teresa A. Zimmers, Carlos T. Moraes
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
Carlos T. Moraes
Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Corresponding Author

Email: cmoraes@med.miami.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XW AMP TAZ CTM. Performed the experiments: XW AMP. Analyzed the data: XW AMP TAZ CTM. Wrote the paper: XW AMP TAZ CTM.