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Research Article

Microfluidic Chip for Molecular Amplification of Influenza A RNA in Human Respiratory Specimens

  • Qingqing Cao equal contributor,

    equal contributor Contributed equally to this work with: Qingqing Cao, Madhumita Mahalanabis

    Affiliation: Department of Mechanical Engineering, Boston University, Boston, Massachusetts, United States of America

    X
  • Madhumita Mahalanabis equal contributor,

    equal contributor Contributed equally to this work with: Qingqing Cao, Madhumita Mahalanabis

    Affiliation: Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

    X
  • Jessie Chang,

    Affiliation: Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

    X
  • Brendan Carey,

    Affiliation: Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

    X
  • Christopher Hsieh,

    Affiliation: Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

    X
  • Ahjegannie Stanley,

    Affiliation: Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

    X
  • Christine A. Odell,

    Affiliation: Department of Pediatrics, Division of Pediatric Emergency Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Patricia Mitchell,

    Affiliation: Department of Emergency Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • James Feldman,

    Affiliation: Department of Emergency Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Nira R. Pollock,

    Affiliation: Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Catherine M. Klapperich mail

    catherin@bu.edu

    Affiliations: Department of Mechanical Engineering, Boston University, Boston, Massachusetts, United States of America, Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

    X
  • Published: March 22, 2012
  • DOI: 10.1371/journal.pone.0033176

About the Authors

Qingqing Cao, Catherine M. Klapperich
Department of Mechanical Engineering, Boston University, Boston, Massachusetts, United States of America
Madhumita Mahalanabis, Jessie Chang, Brendan Carey, Christopher Hsieh, Ahjegannie Stanley, Catherine M. Klapperich
Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
Christine A. Odell
Department of Pediatrics, Division of Pediatric Emergency Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, United States of America
Patricia Mitchell, James Feldman
Department of Emergency Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, United States of America
Nira R. Pollock
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: catherin@bu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QC MM CAO PM JF NP CMK. Performed the experiments: QC MM JC BC CH AS CAO PM. Analyzed the data: QC MM JC CAO PM JF NP CMK. Contributed reagents/materials/analysis tools: CAO PM JF NP CMK. Wrote the paper: QC MM CAO PM JF NP CMK.