Decrease of miR-146b-5p in Monocytes during Obesity Is Associated with Loss of the Anti-Inflammatory but Not Insulin Signaling Action of Adiponectin

Maarten Hulsmans; Els Van Dooren; Chantal Mathieu; Paul Holvoet

doi:10.1371/journal.pone.0032794

Loading metrics

Open Access

Peer-reviewed

Research Article

Decrease of miR-146b-5p in Monocytes during Obesity Is Associated with Loss of the Anti-Inflammatory but Not Insulin Signaling Action of Adiponectin

Maarten Hulsmans,

Affiliation Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
⨯
Els Van Dooren,

Affiliation Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
⨯
Chantal Mathieu,

Affiliation Clinical and Experimental Endocrinology Unit, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
⨯
Paul Holvoet

* E-mail: paul.holvoet@med.kuleuven.be

Affiliation Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
⨯

Decrease of miR-146b-5p in Monocytes during Obesity Is Associated with Loss of the Anti-Inflammatory but Not Insulin Signaling Action of Adiponectin

Maarten Hulsmans,
Els Van Dooren,
Chantal Mathieu,
Paul Holvoet

Published: February 29, 2012
https://doi.org/10.1371/journal.pone.0032794

About the Authors

Maarten Hulsmans

Affiliation Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium

Els Van Dooren

Affiliation Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium

Chantal Mathieu

Affiliation Clinical and Experimental Endocrinology Unit, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium

Paul Holvoet

* E-mail: paul.holvoet@med.kuleuven.be

Affiliation Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MH PH. Performed the experiments: MH EVD. Analyzed the data: MH EVD PH. Contributed reagents/materials/analysis tools: CM. Wrote the paper: MH PH.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Adiponectin
Is the Subject Area "Adiponectin" applicable to this article?

Thanks for your feedback.
Monocytes
Is the Subject Area "Monocytes" applicable to this article?

Thanks for your feedback.
Obesity
Is the Subject Area "Obesity" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Insulin signaling
Is the Subject Area "Insulin signaling" applicable to this article?

Thanks for your feedback.
DNA-binding proteins
Is the Subject Area "DNA-binding proteins" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Reactive oxygen species
Is the Subject Area "Reactive oxygen species" applicable to this article?

Thanks for your feedback.