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Research Article

Hyccin, the Molecule Mutated in the Leukodystrophy Hypomyelination and Congenital Cataract (HCC), Is a Neuronal Protein

  • Elisabetta Gazzerro equal contributor mail,

    equal contributor Contributed equally to this work with: Elisabetta Gazzerro, Simona Baldassari

    elisabettagazzerro@ospedale-gaslini.ge.it

    Affiliation: Muscular and Neurodegenerative Disease Unit, G. Gaslini Institute, University of Genoa, Genoa, Italy

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  • Simona Baldassari equal contributor,

    equal contributor Contributed equally to this work with: Elisabetta Gazzerro, Simona Baldassari

    Affiliation: Muscular and Neurodegenerative Disease Unit, G. Gaslini Institute, University of Genoa, Genoa, Italy

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  • Caterina Giacomini,

    Affiliation: Neuroscience Section, Department of Experimental Medicine, University of Genoa, Genoa, Italy

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  • Veronica Musante,

    Affiliation: Muscular and Neurodegenerative Disease Unit, G. Gaslini Institute, University of Genoa, Genoa, Italy

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  • Floriana Fruscione,

    Affiliation: Muscular and Neurodegenerative Disease Unit, G. Gaslini Institute, University of Genoa, Genoa, Italy

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  • Veronica La Padula,

    Affiliation: Neuroscience Section, Department of Experimental Medicine, University of Genoa, Genoa, Italy

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  • Roberta Biancheri,

    Affiliation: Department of Neuroscience, G. Gaslini Institute, Genoa, Italy

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  • Sonia Scarfì,

    Affiliation: Biochemistry Section, Department of Experimental Medicine, University of Genoa, Genoa, Italy

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  • Valeria Prada,

    Affiliation: Department of Neurology and Genetics, San Martino Hospital, University of Genoa, Genoa, Italy

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  • Federica Sotgia,

    Affiliation: Department of Cancer Biology, Kimmel Cancer Center, and the Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Ian D. Duncan,

    Affiliation: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Federico Zara,

    Affiliation: Muscular and Neurodegenerative Disease Unit, G. Gaslini Institute, University of Genoa, Genoa, Italy

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  • Hauke B. Werner,

    Affiliation: Department of Neurogenetics, Max-Planck Institute of Experimental Medicine, Göttingen, Germany

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  • Michael P. Lisanti,

    Affiliation: Department of Cancer Biology, Kimmel Cancer Center, and the Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Lucilla Nobbio,

    Affiliation: Department of Neurology and Genetics, San Martino Hospital, University of Genoa, Genoa, Italy

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  • Anna Corradi,

    Affiliation: Neuroscience Section, Department of Experimental Medicine, University of Genoa, Genoa, Italy

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  • Carlo Minetti

    Affiliation: Muscular and Neurodegenerative Disease Unit, G. Gaslini Institute, University of Genoa, Genoa, Italy

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  • Published: March 26, 2012
  • DOI: 10.1371/journal.pone.0032180

About the Authors

Elisabetta Gazzerro, Simona Baldassari, Veronica Musante, Floriana Fruscione, Federico Zara, Carlo Minetti
Muscular and Neurodegenerative Disease Unit, G. Gaslini Institute, University of Genoa, Genoa, Italy
Caterina Giacomini, Veronica La Padula, Anna Corradi
Neuroscience Section, Department of Experimental Medicine, University of Genoa, Genoa, Italy
Roberta Biancheri
Department of Neuroscience, G. Gaslini Institute, Genoa, Italy
Sonia Scarfì
Biochemistry Section, Department of Experimental Medicine, University of Genoa, Genoa, Italy
Valeria Prada, Lucilla Nobbio
Department of Neurology and Genetics, San Martino Hospital, University of Genoa, Genoa, Italy
Federica Sotgia, Michael P. Lisanti
Department of Cancer Biology, Kimmel Cancer Center, and the Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Ian D. Duncan
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America
Hauke B. Werner
Department of Neurogenetics, Max-Planck Institute of Experimental Medicine, Göttingen, Germany

Corresponding Author

Email: elisabettagazzerro@ospedale-gaslini.ge.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EG RB FZ HBW MPL AC CM. Performed the experiments: EG SB CG VM FF LN VLP SS VP FS. Analyzed the data: EG LN RB SS FS IDD FZ HBW MPL AC CM. Contributed reagents/materials/analysis tools: EG SS FS FZ MPL AC CM. Wrote the paper: EG SB FF AC CM.