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Research Article

A Chemical Analog of Curcumin as an Improved Inhibitor of Amyloid Abeta Oligomerization

  • Robert A. Orlando mail,

    rorlando@salud.unm.edu

    Affiliation: Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, Albuquerque, New Mexico, United States of America

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  • Amanda M. Gonzales,

    Affiliation: Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, Albuquerque, New Mexico, United States of America

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  • Robert E. Royer,

    Affiliation: Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, Albuquerque, New Mexico, United States of America

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  • Lorraine M. Deck,

    Affiliation: Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico, United States of America

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  • David L. Vander Jagt

    Affiliation: Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, Albuquerque, New Mexico, United States of America

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  • Published: March 19, 2012
  • DOI: 10.1371/journal.pone.0031869

About the Authors

Robert A. Orlando, Amanda M. Gonzales, Robert E. Royer, David L. Vander Jagt
Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, Albuquerque, New Mexico, United States of America
Lorraine M. Deck
Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico, United States of America

Corresponding Author

Email: rorlando@salud.unm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RAO. Performed the experiments: RAO AMG. Analyzed the data: RAO AMG RER LMD DLVJ. Contributed reagents/materials/analysis tools: RAO RER LMD DLVJ. Wrote the paper: RAO RER LMD DLVJ.