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Research Article

GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity

  • Jieru Egeria Lin equal contributor,

    equal contributor Contributed equally to this work with: Jieru Egeria Lin, Adam Eugene Snook, Peng Li

    Affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Adam Eugene Snook equal contributor,

    equal contributor Contributed equally to this work with: Jieru Egeria Lin, Adam Eugene Snook, Peng Li

    Affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Peng Li equal contributor,

    equal contributor Contributed equally to this work with: Jieru Egeria Lin, Adam Eugene Snook, Peng Li

    Affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Brian Arthur Stoecker,

    Affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Gilbert Won Kim,

    Affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Michael Sullivan Magee,

    Affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Alex Vladimir Mejia Garcia,

    Affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Michael Anthony Valentino,

    Affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Terry Hyslop,

    Affiliation: Divison of Biostatistics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Stephanie Schulz,

    Affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Scott Arthur Waldman mail

    Scott.Waldman@Jefferson.edu

    Affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Published: February 22, 2012
  • DOI: 10.1371/journal.pone.0031686

About the Authors

Jieru Egeria Lin, Adam Eugene Snook, Peng Li, Brian Arthur Stoecker, Gilbert Won Kim, Michael Sullivan Magee, Alex Vladimir Mejia Garcia, Michael Anthony Valentino, Stephanie Schulz, Scott Arthur Waldman
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Terry Hyslop
Divison of Biostatistics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: Scott.Waldman@Jefferson.edu

Competing Interests

The authors have read the journal's policy and have the following conflicts: This study was partly funded by Targeted Diagnostic and Therapeutics Inc. Dr. Waldman is the Chair (uncompensated) of the Scientific Advisory Board of Targeted Diagnostics and Therapeutics, Inc., which has a license to commercialize inventions related to this work. Dr. Waldman is the Samuel M.V. Hamilton Endowed Professor. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: JEL AES PL SS SAW. Performed the experiments: JEL AES PL BAS GWK MSM AVMG. Analyzed the data: JEL PL TH. Contributed reagents/materials/analysis tools: MAV. Wrote the paper: JEL AES SAW.