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Research Article

Trans-Synaptic Spread of Tau Pathology In Vivo

  • Li Liu,

    Affiliation: Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America

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  • Valerie Drouet,

    Affiliation: Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America

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  • Jessica W. Wu,

    Affiliation: Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America

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  • Menno P. Witter,

    Affiliation: Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Trondheim, Norway

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  • Scott A. Small,

    Affiliation: Department of Neurology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America

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  • Catherine Clelland,

    Affiliation: Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America

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  • Karen Duff mail

    ked2115@columbia.edu

    Affiliations: Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America, Department of Psychiatry, New York State Psychiatric Institute, New York, New York, United States of America

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  • Published: February 01, 2012
  • DOI: 10.1371/journal.pone.0031302

About the Authors

Li Liu, Valerie Drouet, Jessica W. Wu, Catherine Clelland, Karen Duff
Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America
Menno P. Witter
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Trondheim, Norway
Scott A. Small
Department of Neurology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America
Karen Duff
Department of Psychiatry, New York State Psychiatric Institute, New York, New York, United States of America

Corresponding Author

Email: ked2115@columbia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KD. Performed the experiments: LL VD JWW. Analyzed the data: LL VD CC MW SAS CC KD. Contributed reagents/materials/analysis tools: CC KD. Wrote the paper: KD SAS LL VD MW CC. Performed most of the technical aspects of the project: LL. Performed qRT-PCR experiments: VD. Assisted with LCM experiments: JWW. Contributed technical expertise for the qRT-PCR and LCM: CC.