Caffeic Acid Phenethyl Ester Causes p21Cip1 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells

Hui-Ping Lin; Shih Sheng Jiang; Chih-Pin Chuu

doi:10.1371/journal.pone.0031286

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Open Access

Peer-reviewed

Research Article

Caffeic Acid Phenethyl Ester Causes p21^Cip1 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells

Hui-Ping Lin,

Affiliations Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan, Translational Center for Glandular Malignancies, National Health Research Institutes, Miaoli, Taiwan
⨯
Shih Sheng Jiang,

Affiliations Translational Center for Glandular Malignancies, National Health Research Institutes, Miaoli, Taiwan, National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
⨯
Chih-Pin Chuu

* E-mail: cpchuu@nhri.org.tw

Affiliations Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan, Translational Center for Glandular Malignancies, National Health Research Institutes, Miaoli, Taiwan, Graduate Program for Aging, China Medical University, Taichung, Taiwan
⨯

Caffeic Acid Phenethyl Ester Causes p21^Cip1 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells

Hui-Ping Lin,
Shih Sheng Jiang,
Chih-Pin Chuu

Published: February 7, 2012
https://doi.org/10.1371/journal.pone.0031286

About the Authors

Hui-Ping Lin

Affiliations Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan, Translational Center for Glandular Malignancies, National Health Research Institutes, Miaoli, Taiwan

Shih Sheng Jiang

Affiliations Translational Center for Glandular Malignancies, National Health Research Institutes, Miaoli, Taiwan, National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan

Chih-Pin Chuu

* E-mail: cpchuu@nhri.org.tw

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CPC. Performed the experiments: HPL. Analyzed the data: SSJ. Contributed reagents/materials/analysis tools: CPC. Wrote the paper: CPC HPL SSJ.

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Cancer treatment
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Prostate cancer
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Cyclins
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Gene expression
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Phosphorylation
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Transcription factors
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Apoptosis
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Cell cycle inhibitors
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